- In ACTIVExtend, patients who had completed 18 months of TYMLOS (abaloparatide) injections or placebo in the ACTIVE Phase 3 trial were transitioned to receive 24 additional months of open-label alendronate.
- “There is a substantial unmet medical need among postmenopausal women with osteoporosis at high risk of a fracture and we believe that these women deserve access to proper diagnosis and early intervention,” said Dr. Lorraine Fitzpatrick, Radius Health’s Chief Medical Officer. “Patients who have had a fracture are at a five-fold risk of a subsequent fracture and reducing fracture risk should be the goal of treatment.”
“We are extremely pleased with the results of the landmark ACTIVExtend trial which provides physicians, payers and patients with new insights into a treatment paradigm which targets building bone with an anabolic first line and then extending the benefit of fracture risk reduction with a low cost antiresorptive agent,” said Dr. Bruce Mitlak, Radius Health’s Vice President of Clinical Development. “The results from this program demonstrate that TYMLOS followed by alendronate can support this paradigm with sustained fracture risk reduction through 3.5 years.”
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