=AnaptysBio (ANAB) : positive proof-of-concept data for ANB020

• Headquarters: San Diego, CA
• Founded: 2005
• anaptysbio.com

AnaptysBio announces positive proof-of-concept data for ANB020, its investigational anti-IL-33 therapeutic antibody, in an ongoing Phase 2a clinical trial in adult patients with moderate-to-severe atopic dermatitis

"Moderate-to-severe atopic dermatitis is a serious disease associated with chronic skin inflammation and debilitating pruritus, with a clear unmet medical need," said Dr. Graham Ogg, professor of dermatology at University of Oxford and primary investigator of the Phase 2a study. "The rapid and sustained benefit observed in patients after a single dose of ANB020 is an encouraging interim result from this trial. I look forward to the continued development of ANB020 as a potential future therapeutic option for patients suffering from this disease."

• The average baseline EASI score upon enrollment was 32. The average EASI score reduction and pruritus score reduction at seven days post-placebo administration was four percent and 10 percent, respectively. All 12 patients were inadequately controlled by topical corticosteroids and seven were treated with systemic non-biologic anti-inflammatory therapy prior to the screening washout period of this trial.
• Rapid clinical response was observed at day 15 post-ANB020 administration with nine of 12 patients (75 percent) achieving EASI-50, of which three patients (25 percent) also achieved EASI score improvement of 75 percent relative to baseline (EASI-75). The average EASI score reduction at day 15 was 58 percent and the average pruritus reduction was 28 percent relative to baseline.
• At day 29 post-ANB020 administration, 10 of 12 patients (83 percent) achieved EASI-50, of which four patients (33 percent) also achieved EASI-75. The average EASI score reduction at this time point was 61 percent and the average pruritus reduction was 32 percent relative to baseline.
• Sustained clinical response was observed at day 57 post-ANB020 administration, with nine of 12 patients (75 percent) achieving EASI-50, of which five patients (42 percent) also achieved EASI-75. Average EASI reduction was 62 percent and the average pruritus reduction was 21 percent relative to baseline.
• Exploratory biomarker assessment indicated reduction of granulocyte infiltration into localized skin lesions by an average of 30 percent amongst all patients and 60 percent among the 10 patients achieving EASI-50 at 29 days post-ANB020 administration, while exploratory cytokine biomarker levels were below detection limit and therefore inconclusive.
• ANB020 was generally well-tolerated by all patients and no severe adverse events have been reported to date. The most frequent treatment-emergent adverse events reported were mild dizziness in two patients subsequent to placebo dosing, and mild headache in two patients post-ANB020 administration.

Description

AnaptysBio, Inc. is a United States-based biotechnology company. The Company is engaged in developing antibody product candidates focused on unmet medical needs in inflammation and immuno-oncology. The Company develops its product candidates using its antibody discovery technology platform, which is designed to replicate, in vitro, the natural process of antibody generation. Its product pipeline includes ANB020 and ANB019, which are being developed to treat severe inflammatory disorders with unmet medical need. The Company's ANB020 product candidate is an antibody that inhibits the activity of interleukin-33, and is used for the treatment of severe adult asthma and severe adult peanut allergy. In addition, the Company is engaged in developing its ANB019 product candidate, an antibody that inhibits the interleukin-36 receptor, for the treatment of rare inflammatory diseases called generalized pustular psoriasis (GPP) and palmoplantar pustular psoriasis (PPP).

Key stats and ratios

	Q2 (Jun '17)	2016
Net profit margin	-38.34%	-25.53%
Operating margin	-36.50%	-18.13%
EBITD margin	-	-16.73%
Return on average assets	-8.23%	-7.19%
Return on average equity	-9.82%	-
Employees	49